[Does permanent cardiac stimulation through B - type natriuretic peptide secretion influence the basic parameters of renal function?].

UNLABELLED Aberrant waveform during artificial pacing increases secretion of natriuretic peptides, mainly B-type natriuretic peptide (BNP). The aim of the study was to investigate whether renal function is modified through increased BNP secretion during artificial pacing. MATERIAL AND METHODS A total of 117 patients with pacemaker implanted were included (pacing mode: AAI/R - 21, DDD/R - 59, VVWl/R - 37) and 48 healthy volunteers served as controls. Serum BNP, creatinine and urea, levels were measured prior to, three and six months after pacemaker implantation. RESULTS Three and six months after implantation BNP level significantly increased in DDD/R group, urea level increased in AAI/R group whereas creatinine level increased in DDD/R and WI/R group. CONCLUSIONS In patients after pacemaker implantation BNP level increases in DDD/R pacing mode group whereas in other modes it remains stable. Pacemaker implantation leads to changes in renal function. B-type natriuretic peptide level may serve as a useful parameter forrenal and cardiac function assessment after pacemaker implantation.